Recent Developments in Toxicology: Trends, Methods and Problems

InhaltsangabeNeurotoxicology of different noxious compounds.- In vitro assessment of antidotes to organophosphorus toxicity.- Primary cultures of adult mammalian sensory neurons and other in vitro systems of use in neurotoxicological studies.- Animal models in behavioural toxicology and teratology.- Cytotoxic brain oedema as a model in the examination of cerebroprotective substances.- Neurochemical characterization of hexachlorophene induced brain oedema.- The effects of organophosphorus compounds on the central nervous system of rats.- The effects of n-hexane and its metabolites on erythrocyte and synaptosome membrane acetylcholinesterease in vitro.- New Aspects and Methods in Toxicopathology.- Assessment of toxicopathological effects in ageing laboratory rodents.- New microtechniques in toxicopathology.- Tumor Registry Data Base: Systematized nomenclature of preneoplastic and neoplastic lesions in rat gonads.- Mortality and neoplastic lesions in untreated Sprague Dawley rats.- Investigations on the sensitivity of several biochemical and histological methods after liver intoxication induced by pentachlorophenol and carbon tetrachloride.- The glutathione system in rat liver chronically injured by thioacetamide.- Hitherto unknown additive growth effects of fluorene and 2-acetylaminofluorene on bile duct epithelium and hepatocytes in rats.- Morphological lesions of pancreas and bile ducts in rats induced by dibutyltin dichloride.- Toxic action of platinum coordination complexes on the endocrine pancreas of the rat.- Investigations of myelotoxic effects in rats.- The effect of aluminium loading on bones of mice.- Cobalt particles, identified by energy dispersive X ray microanalysis, in diamond polisher's lung.- Density of gastroendocrine cells in cynomolgus monkey and other species.- Computerised analysis of pathological findings in longterm trials of phenylmercuric acetate in rats.- Cardiovascular Toxicology.- Preclinical assessment of the cardiotoxic potential of anthracycline antibiotics: N-L-leucyl-doxorubicin.- Hypertension is not exacerbated by chronic carbon monoxide exposure, with or without added salt, in the borderline hypertensive rat.- Cardiovascular system and kidney as specific targets of chronic exposure to vanadate in the rat: functional and morphological findings.- Acute effects of dichloromethane on arrhythmia development during the early phase of myocardial ischemia and reperfusion in the rat.- Pharmacokinetics of total and free digoxin and Fab fragments in five intoxicated patients after administration of specific anti-digoxin Fab fragments.- Use of spontaneously beating heart muscle cells differentiating from pluripotential embryonic stem cells for testing of chronotropic agents.- Characterization of the hypotensive side effects of macrolide antibiotics in animals.- Toxic Effects on Haemostasis.- Toxic influence on platelet system.- Hereditary and acquired disturbances of haemostasis in animals.- Effects of snake venoms on tissue-type plasminogen activator release.- Metabolic and toxicological studies on the anticoagulant rodenticide, flocoumafen.- Influence of natural humic acids and synthetic phenolic polymers on haemostasis.- A comparison of the thrombogenic activity of prothrombin complex concentrates using stasis and non-stasis models.- Inhibition of platelet aggregation and thromboxane A2 production by chlorophenoxy acid herbicides.- Toxic Effects on Liver and Kidney.- The effect of paracetamol on the hepatic uptake of microparticles in vivo and in vitro.- Influence of iron chelators, 1,2-dialkyl-3-hydroxypyridin-4-ones, on the lipid peroxidation and glutathione level in the liver of mice.- The influence of cytochrome P 450 inducers on carbonyl-reduction in mouse liver.- Influence of inducers of cytochrome P 450 on dealkylation of 7-alkoxycoumarins.- The effect of monoclonal antibodies on dipyrone-induced rat liver cytochrome P 450.- Antipyrine metabolism in coke oven workers.- Influence of bile acids on the develop