Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances

InhaltsangabeYoung Scientists Award Lecture 1988.- m-Dinitrobenzene: Studies on its Toxicity to the Testicular Sertoli Cell.- Mechanism of Metal Carcinogenicity.- Metals-Epidemiological and Experimental Evidence for Carcinogenicity.- Mechanistic Aspects of Chromium Carcinogenicity.- Mechanistic Aspects of Nickel Carcinogenicity.- Differing Effects of Chromium (III) and Chromium (VI) on Nucleotides and DNA.- Individual Biomonitoring of Chemical Exposure.- Nucleic Acid-Carcinogen Adducts in Human Dosimetry.- Molecular Dosimetry of Genotoxic Damage.- Protein-Carcinogen Adducts in Human Dosimetry.- Individual Exposure Monitoring from Plasma or Urinary Metabolite Determination.- 32P-Postlabelling of DNA Adducts in White Blood Cells of Foundry Workers.- A Sensitive Method for the Determination of Urinary Mercapturic Acids for Use in Biological Monitoring.- Biological Monitoring of Exposure to Ethylene Glycol Ethers.- Liver Damage after Coal-tar Treatment does not Prevent Induction of Glutathione S-Transferases in Rat Liver.- The Significance of Urinary Thioethers as Indicators of Exposure to Alkylating Agents.- Ethylenethiourea as an Indicator of Exposure to Ethylenebisdithiocarbamate Fungicides.- Application of Flame Atom Trapping and Column Preconcentration Techniques to the Measurement of Cadmium in Urine.- Different Affinity of Erythrocyte Glutathione-S-Transferase to Methyl Chloride in Humans.- The Combinations of Inducers of the Coumarin Hydroxylase-Locus Help Investigate their Mode of Action.- Genes for Drug Metabolizing Enzymes.- Gene Structure and Regulation of Cytochrome P-450.- Evidence for Several Hepatic Proteins Related to Microsomal Epoxide Hydrolase.- Expression of Drug Metabolizing Enzymes in Eucaryotic Cells.- Expression of P-450 Enzyme Activities in Heterologous Cells by Transfection.- of Cytochrome P-450 Genes into V79 Chinese Hamster Cells to Generate New Mutagenicity Test Systems.- Immunotoxicology.- Thymus Atrophy and Immunosuppression Induced by Organotin Compounds.- An Immunohistochemical Study of Dibutyltin-Induced Thymus Atrophy.- Inhibition of Phytohemagglutinine-Induced T Lymphocyte Proliferation by 6-(octadecyldithio)purine, a Novel Liposomal Prodrug of 6-mercaptopurine.- Effects of Ammonia Caramel and Tetrahydroxybutylimidazole on the Immune System of Rats.- The Popliteal Lymphnode Assay (PLNA) in Rodents: A Simple Functional Test for Detecting Sensitizing Effects of Xenobiotics.- Comparative Study on the Toxicity of Acetaminophen and Mercuric Chloride in Normal and Athymic Mice and Rats.- Significance of Serum Ferritin Concentrations in Lung Cancer and it's Relation with Cellular Immunity.- Carcinogenesis.- Metabolic Activation of Diethylstilbestrol and 7,8-Benzoflavone in Hamster Hepatocytes.- Prostaglandin-H-Synthase Catalyzed Formation of Reactive Intermediates from Stilbene and from Steroid Estrogens: Covalent Binding to Proteins.- Hypomethylation of c-myc Proto-oncogene of N-Nitrosomorpholine - Induced Rat Liver Nodules and of H4IIE Cells.- Determination of 7-(2-Oxoethyl)guanine and N2,3-Ethenoguanine in DNA Hydrolysates by HPLC.- Detection of Acrolein Congener-DNA Adducts Isolated from Cellular Systems.- The DNA-Adducts of the Food Mutagen and Carcinogen IQ (2-amino- 3-methylimidazo[4,5-f] quinoline).- The Role of Extrahepatic Organs in the First Pass Metabolism of N-Nitrosodibutylamine.- Modulation of 17 ?-Ethinylestradiol and 7,8-Benzoflavone Metabolism in Hamster Liver Microsomes is Possibly Related to Hepatot Tumorigenesis.- Incidence of Preneoplastic Foci in Rat Liver Dependent on Different Promoting Schemes.- Metabolism and Endogenous Production of Ethylene in a Rat and Man.- Pharmacokinetics of Propylene and its Reactive Metabolite Propylene Oxide in Sprague-Dawley Rats.- Detection of DNA-Protein Crosslinks in the Kidney of Male B6C3F1 Mice after Exposure to Methyl Chloride.- Species Differences in DNA-Damage by Butadiene: Role of Diepoxybutane.- Determination of 7-(2-hydroxyethyl)Guanine with Gas Chr