Sourcebook of Models for Biomedical Research

RezensionFrom the reviews:"Conn, a distinguished scientist. has created one of the most significant and comprehensive model reference tools in recent years. provides a system of relevancy that leads the serious student to adapt the model to their own different and perhaps unique research applications. The essays have a sufficient number of tables and overwhelmingly black-and-white figures and photographs to assist in comprehension. Very useful for libraries serving upper-division and graduate students in the life sciences." (John M. Robson, American Reference Books Annual, 2009)"Sourcebook of Models for Biomedical Research is a collection of the various models developed over several decades in biomedicine. The chapters are presented clearly, easy to understand, and interesting to read. In summary, this book would be a great addition to the library of anyone who is interested in an overview of model development for biomedical research." (Dongwen Wang, The Quarterly Review of Biology, Vol. 85 (3), September, 2010)

The collection of systems represented in the Sourcebook of Models for Biomedical Research reflect the diversity and utility of models that are used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. Some models have the advantage that the reproductive, mitotic, development or aging cycles are rapid compared with those in humans; others are utilized because individual proteins may be studied in an advantageous way and have human homologs. Other organisms are facile to grow in laboratory settings, lend themselves to convenient analyses, have defined genomes or present especially good human models of human or animal disease. The Sourcebook of Models for Biomedical Research is a comprehensive and extensive collection of these important medical parallels. While the entire book is not devoted to the remarkable success of the genomic programs, this work is well represented and indexed within these pages. This volume will be an invaluable resource for pharmaceutical and academic researchers across a wide range of biological fields.

Animal models for human diseases: an overview.- Selection of biomedical animal models.- Improved models for animal research.- The ethical basis for animal use in research.- Bibliographic searching tools on disease models to locate alternatives for animals in research: A website companion.- NIH policies on sharing of model organisms and related research resources.- Databases for biomedical animal resources.- Psychological enrichment for animals in captivity.- Integrated network modeling of molecular and genetic interactions.- The sponge as a model of cellular recognition.- Sea urchin embryo ¿ a model system for analyzing a variety of cellular activities during early development.- C. elegans models of human neurodegenerative deseases: a powerful tool to identify molecular mechanisms and novel therapeutic targets.- Zebrafish as a model for development.- Zebrafish as a model for studying adult effects of challenges to the embryonic nervous system.- Modeling cognitive and neurodegenerative disorders in Drosophila melanogaster.- Biomedical research with honey bees.- Establishing and maintaining a Xenopus laevis colony for research laboratories.- The chicken as a model organism.- Rat knockout and mutant models.- Rodent genetics, models, and genotyping methods.- The house mouse in biomedical research.- Mouse model for Alzheimer's disease.- Guinea pigs as models for human cholesterol and lipoprotein metabolism.- Reliability of rodent models.- The domestic cat, Felis catus, as a model of hereditary and infectious disease.- Swine in biomedical research.- The minipig as animal model in biomedical stem cell research.- The non-human primate as a model for biomedical research.- Primates as models of behavior in biomedical research.- Primate models for understanding brain mechanisms of cognitive behavior.- Animal models for eye diseases and therapeutics.- Animal models of noise induced hearing loss.- Human and animal models for the study of muscle pain.- Animal models of Parkinson's disease.- Transgenic animal model of neurodegenerative diseases.- Animal models of nociception and pain.- Non-mammalian models for the study of pain.- Animal models of vascular development and endothelial cell biology.- Models of behavior: Cardiovascular.- Animal models for atherosclerosis, restenosis, and endovascular aneurysm repair.- Transgenic mouse models of HIV-1/AIDS and cardiac performance.- Primate models for the assisted reproductive technologies and embryonic stem cell biology.- Rat models of Polycystic Ovary Syndrome (PCO).- Murine models for reproduction.- Pig model to study dynamics of steroids during the ovarian follicular growth and maturation.- Molecular genetic approach to identify inhibitors of signal transduction pathways. Fission yeast as a model system for drug discovery.- Yeast as a model system to study DNA damage and DNA repair.- Human models of space physiology.- Developmental space biology of mammals: concepts and methods of study.- A practical approach to animal models of Sepsis.- Animals models in functional magnetic resonance imaging.- Animal models in aging research: a critical examination.- Gene targeting in human somatic cells.- Animal models for investigating the causes and mechanisms of mammalian germ cell aneuploidy.- Genetic models of Alzheimer's disease.- Rat models of experimental autoimmune encephalomyelitis.- Animal models in virology.- Nonhuman primate models for AIDS.- Use of congenic mouse strains for candidate disease gene identification in complex traits.- Animal models of sudden infant death syndrome.- Animal models of Post Traumatic Stress Disorder.- Animal models for studying fetal alcohol syndrome, alcohol-related birth defects, and alcohol-related neurodevelopmental disorder.- Modeling drug and alcohol abuse: experimental examples of the utility of zebrafish.- Mouse models for experimental cancer therapy.- Rat models of skin wound healing.- Animal models of prostate cancer ...